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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Hum Reprod. 2018 Jul 1;33(7):1331–1341. doi: 10.1093/humrep/dey114

Figure 3.

Figure 3

Frequency histograms of O-M values for m.3243A>G and m.8993T>G transmissions. Heteroplasmy data from blood for mother to child transmissions were compiled from published studies of the m.3243A>G (n=111) and the m.8993T>G mutation (n=118). The blood heteroplasmy for the m.3243A>G mutation was corrected for age to avoid potential bias. O-M values represent the ratio in heteroplasmy between generations (O=offspring, M=mother) of A) m.3243A>G and B) m.8993T>G Frequency. Histograms were plotted for both mutations, and a Gaussian curve fitted to each plot.