Skip to main content
. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: Hum Reprod. 2018 Jul 1;33(7):1331–1341. doi: 10.1093/humrep/dey114

Table 4. Relative contribution of genetic drift and selection contribute to the segregation of three mtDNA mutations.

Segregational mechanism m.3243A>G m.8993T>G m.14487T>C
Genetic drift? + + +
Selection on OXPHOS function?
  • -

    OXPHOS assembly affected?

  • -

    ATP generating capacity affected?

  • -

    Membrane potential (‘selection sensor’) affected

 NEGATIVE
At 90-100% OXPHOS
assembly lost (CI)
>80% respiratory
defect ATP drops
Severely reduced		 POSITIVE

Only CV affected

100%: residual activity
20-30%

Higher due to
inefficient coupling		 NEUTRAL

Stability and assembly
CI affected

OXPHOS capacity
preserved

No effect

CI, complex I. CV, complex V.