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Mitochondrial RNA expression is reduced in chronic obstructive pulmonary disease (COPD) patients. Quadriceps expression of 12S and 16S rRNAs were quantified in samples from COPD (n = 40) and controls (n = 14). A and B: expression of both the 12S rRNA (A) and 16S rRNA (B) were reduced in the patients compared with controls. AU, arbitrary units. C: the reduction in the 12S rRNA was larger than that in the 16S rRNA leading to a reduction in the 12S:16S ratio (C).
