Skip to main content
. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: ACS Appl Bio Mater. 2018 Aug 10;1(3):643–651. doi: 10.1021/acsabm.8b00141

Figure 1.

Figure 1

Scheme and stability of the siRNA–PNA chimera at physiological temperature. (A) Scheme of the siRNA–PNA chimera. siRNA duplex containing an extended sequence at the 3′ end of the sense strand was annealed with PNA at a 1:1 molar ratio. The chimeras were then incubated at 37 °C for a series of time intervals to evaluate their stability. (B) Stability of the chimera formed with the 8-mer PNA CACCACTC. (C) Stability of the chimera formed with the 9-mer PNA CACCACCAC.