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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: ACS Appl Bio Mater. 2018 Aug 10;1(3):643–651. doi: 10.1021/acsabm.8b00141

Figure 2.

Figure 2

Serum stability of the siRNA–PNA chimeras annealed at different termini of the siRNA. The luciferase siRNA was annealed to the 9-mer PNA (CACCACCAC) at the 5′ and 3′ termini of the sense and antisense strands. The chimeras were incubated in 50% rat serum at 37 °C for a series of time points. Serum stability of the samples was evaluated by electrophoresis on a 20% native polyacrylamide gel and visualized by staining with GelRed. Intensities of the gel bands were quantitated with ImageJ. Results are presented as mean ± SD (n = 3 independent experiments).