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. Author manuscript; available in PMC: 2019 Jun 5.
Published in final edited form as: ACS Appl Bio Mater. 2018 Aug 10;1(3):643–651. doi: 10.1021/acsabm.8b00141

Figure 6.

Figure 6

Silencing effect of the PNA–siRNA–PNA chimeras containing a space between the PNA and the antisense strand. The native siRNA or PNA–siRNA–PNA chimeras were cotransfected with the firefly luciferase plasmid and renilla luciferase plasmid using Lipofectamine 2000. A scrambled siRNA was used as the negative control. 48 h after transfection, a dual-luciferase reporter (DLR) assay system was used to detect the relative luciferase expression level of each sample. Results are presented as mean ± SD (n = 3 independent experiments).