TABLE 2.

Infusion Reactions Associated with Rapid IFX (22 Reactions in 21 Patients)

No. Reactions	Sequence of Offending Rapid Infusion	Nature of Reaction	Management
Acute reactions (total = 9 reactions)
3	1st, 4th and 21st	Malaise, headache, and nausea with or without vomiting	Monitoring—Use of acetaminophen with the offending infusions. One patient had corticosteroids for before future infusions.
3	4th, 12th, 17th	Urticaria and pruritus	Monitoring—Use of an antihistaminic with offending infusion and future infusions.
1	22nd	Rash, considered to be possibly Henoch Schonlein purpura or leukocytoclastic skin reaction	Stop IFX and switch to adalimumab.
1	4th	Shortness of breath, chest tightness, hypotension, and desaturation	Stop IFX, IV steroids and antihistamines, then switch to adalimumab.
1	18th	Nasal congestion	Reduced rate of IFX infusion
Delayed reactions (total = 13 reactions)
8	1st × 3, 2nd, 3rd, 4th, 11th, and 12th	Malaise, nausea, headache, and flu-like symptoms	Monitoring—Use of corticosteroids in future infusions—Use all 3 premedications in future infusions—One patient had interval increase of infusions
2	1st and 12th	Rash including petechial eruption	Investigations (INR), dermatology referral, topical corticosteroid ointment
2	1st and 5th	Elevated liver enzymes	Monitoring and investigations to exclude autoimmune hepatitis
1	5th	Develops style after the infusion, lasted for 3 days and then self-resolved	Monitoring

IV, intravenous.