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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Neuron. 2018 Jun 21;99(1):64–82.e7. doi: 10.1016/j.neuron.2018.05.023

Figure 4: Viral QTL detection and association with AD genetics.

Figure 4:

(a) Host DNA markers significantly associated (FDR < 0.25) with viral abundance were classified as vQTL for that feature-tissue combination. (b) Top multi-viral vQTL associations, with overlapping gene symbols and associated viruses. (c) Top vQTL associations where vQTL is also a cis-eQTL for at least one host gene. (d) Sequence kernel association test to evaluate whether vQTL markers are also associated with AD traits. (e) Virus level vQTL sets for HHV-6A were highlighted most strongly, (f) whereas viral feature level associations implicated features from HHV-6A and HSV-1.

(Panels e-f show associations for any viruses/viral features that were implicated in viral differential RNA abundance, P-values < 0.05 shown in cells)