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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Neuron. 2018 Jun 21;99(1):64–82.e7. doi: 10.1016/j.neuron.2018.05.023

Figure 5: Viral regulation of AD associated host networks.

Figure 5:

(a) Integration of vQTL with viral abundance, and host gene expression was used to infer directed virus / host subnetworks. (b) Virus / host gene network sizes for viruses with interactions detected in multiple tissues (c) Host genes that are most frequently perturbed by viruses (d) Host genes upregulated by HHV-6A are enriched for a heterogeneous set of AD risk and biomarker associated genes. Shown here is the HHV-6A / AD-associated gene subnetwork, and detected interactions with additional viruses. (e-g) Brain cis-eQTLs associated with expression of specific virus/host networks are enriched for AD GWAS risk loci.

(P-values shown in cells with FDR < 0.1)