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. Author manuscript; available in PMC: 2019 Jul 11.
Published in final edited form as: Neuron. 2018 Jun 21;99(1):64–82.e7. doi: 10.1016/j.neuron.2018.05.023

Figure 7: Viral perturbation of transcription factor regulatory networks.

Figure 7:

(a) Comparison of virus/host networks with diverse TF-Target networks built from multiple independent AD data sets, to identify virus / TF network enrichments. (b) Examination of the concordance of effect exerted by associated virus and TF upon target genes, and (c) summarization of results across all TF-target networks (d) to identify unanimous virus/TF associations. (e) Kinase enrichment analysis of the most strongly implicated TF identified several kinases that we also detected as regulated by HHV-6A, with known associations to AD and HHV-6A, indicating a potential mechanism for viral co-option of TF networks in AD.