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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Alcohol Clin Exp Res. 2019 Apr 30;43(6):1091–1102. doi: 10.1111/acer.14034

Figure 2. Effects of enzyme nanoparticles of alcohol metabolism on liver injury and blood concentrations of alcohol and acetaldehyde in mice fed with acute alcohol binge and anti-HIV drugs.

Figure 2

Figure 2

Figure 2

(A) Liver histology revealed by H&E staining. Original magnification 200x; (B) Blood alcohol concentrations (BAC) in mice of acute alcohol binge; (C) Blood acetaldehyde concentrations (BADC); (D) Plasma alanine aminotransferase (ALT); PBS, injected with phosphate-buffered saline after the alcohol binge; E, ethanol; PI, injected with anti-HIV protease inhibitors: ritonavir and lopinavir after the alcohol binge; ENP1, injected with the enzyme nanoparticles of complete alcohol degradation after the alcohol binge; PI+ENP1, injected with PI and ENP1 after the alcohol binge; ENP2, injected with the enzyme nanoparticles of partial alcohol degradation after the alcohol binge; PI+ENP2, injected with PI and ENP2 after the alcohol binge; α p<0.05, αα p<0.01 compared to PBS or PI; β p<0.05 compared to ENP1; n=3–5.