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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Alcohol Clin Exp Res. 2019 Apr 30;43(6):1091–1102. doi: 10.1111/acer.14034

Figure 5. Effects of enzyme nanoparticles of alcohol metabolism on hepatic lipogenesis and organelle stresses in mice fed chronic alcohol diet plus acute alcohol binge in the presence of anti-HIV drugs.

Figure 5

Figure 5

(A) Expression of lipogenic factors; ACC, acetyl-CoA carboxylase; LXRα, liver X receptor α; SREBP1c, sterol regulatory element-binding protein 1c; (B) Expression of selected markers for endoplasmic reticulum (ER) stress and Golgi stress; sXbp1, the alternatively spliced form of X-box binding protein 1; CHOP, CCAAT-enhancer-binding protein homologous protein; GCP60, Golgi complex-associated protein 60; (C) Western blots of ER or Golgi stress related proteins; SREBP1c (p), precursor protein of SREBP1c; SREBP1c (n), nuclear or activated SREBP1c; ATF6, activating transcription factor 6; ATF6 (p), precursor ATF6; ATF6 (n), nuclear or activated ATF6; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; (D) Quantitation of the activated ATF6, which was conducted with ImageJ and normalized with GAPDH; Note, the labels for all the experimental treatments are the same as those described in Figure 3. α p<0.05 and αα p<0.01 compared to PBS in the same group; β p<0.01 compared to ENP1 in the same group; γ p<0.05 and γγ p<0.01 compared between EB and EPB at the same time point; n=4.