Table 2.
Comparison of Key Outcomes Pre- and Post-Methenamine Suppression
Pre- methenamine |
Post- methenamine |
p-value | |
---|---|---|---|
UTI rate, n/1000 follow-up days | 9.16 | 5.01 | 0.0001 |
Length of antibiotic therapy to treat UTI, n/1000 follow-up days | 152 | 88 | 0.0022 |
Length of antibiotic suppressive therapy, n/1000 follow-up days | 13.7 | 0 | <0.0001 |
Length of therapy for non-UTI antibiotics, n/1000 follow-up days | 69 | 83 | 0.8655 |
TMP-SMX prophylaxis length of therapy, n/1000 follow-up days | 849 | 895 | 0.7080 |
Hospitalizations due to UTI, n/1000 follow-up days | 2.64 | 1.07 | 0.0456 |
Hospitalizations (other cause), n/1000 patient days | 3.72 | 2.03 | 0.1244 |
Untreated ASB, n/1000 follow-up days | 0.58 | 0.85 | 0.1344 |
Treated ASB, n/1000 follow-up days | 0.66 | 0.85 | 0.2290 |
Culture negative treated UTI, n/1000 follow-up days | 0.83 | 0.96 | 0.8062 |
Creatinine, median | 1.24 | 1.21 | 0.8723 |
GFR ml/min/1.73m2, median | 50.5 | 51.0 | 0.9942 |
Urinary pH, median | 5.50 | 6.00 | 0.3203 |
MDR organisms isolated, % of positive bacteria cultures | 0.08 | 0.07 | 0.6145 |