Table 4.
Multivariable relative risks* and 95% confidence intervals of breast cancer for a 1 SD increase in natural log transformed plasma measure by age at blood, smoking status, alcohol intake, and current multivitamin use at blood collection
| Plasma measure | Cases/Controls | Per 1-SD increase in natural log transformed concentrations RR (95% Cl) | Cases/Controls | Per 1-SD increase in natural log transformed concentrations RR (95% Cl) | P for interaction |
|---|---|---|---|---|---|
| Age at blood <45 years | Age at blood ≥45 years | ||||
| Folate, ng/mL | 281/591 | 1.13 (0.96, 1.32) | 328/614 | 1.04 (0.89, 1.21) | 0.15 |
| Vitamin B12, pg/ml | 280/591 | 1.31 (1.12, 1.54) | 328/615 | 1.10(0.96, 1.27) | 0.02 |
| Pyridoxal 5’-phosphate, pmol/ml | 281/592 | 1.16 (0.98, 1.37) | 329/617 | 1.04 (0.91, 1.19) | 0.20 |
| Homocysteine, nmol/ml | 281/589 | 0.90 (0.77, 1.06) | 328/612 | 1.04 (0.90, 1.21) | 0.04 |
| Cysteine, nmol/ml | 281/592 | 1.00 (0.85, 1.19) | 327/616 | 1.06 (0.92, 1.22) | 0.32 |
| Cysteinylglycine, nmol/ml | 276/588 | 1.00 (0.85, 1.18) | 325/613 | 0.99 (0.86, 1.15) | 0.92 |
| Never/Past Smoker at Blood | Current Smoker at blood | ||||
| Folate, ng/mL | 553/1108 | 1.09 (0.97, 1.22) | 56/96 | 1.01 (0.68, 1.50) | 0.70 |
| Vitamin B12, pg/ml | 552/1109 | 1.24 (1.11, 1.38) | 56/96 | 0.77 (0.52, 1.15) | 0.001 |
| Pyridoxal 5’-phosphate, pmol/ml | 553/1112 | 1.06 (0.95, 1.19) | 57/96 | 1.47 (1.02, 2.12) | 0.12 |
| Homocysteine, nmol/ml | 553/1106 | 0.99 (0.89, 1.10) | 56/94 | 0.79 (0.52, 1.19) | 0.17 |
| Cysteine, nmol/ml | 552/1111 | 1.05 (0.93, 1.17) | 56/96 | 0.96 (0.66, 1.38) | 0.49 |
| Cysteinylglycine, nmol/ml | 546/1105 | 1.04 (0.93, 1.17) | 55/95 | 0.53 (0.33, 0.83) | 0.0001 |
| Alcohol <10 g/day | Alcohol ≥10 g/day | ||||
| Folate, ng/mL | 530/1080 | 1.14 (1.01, 1.28) | 79/125 | 0.83 (0.58, 1.18) | 0.03 |
| Vitamin B12, pg/ml | 529/1081 | 1.22 (1.09, 1.36) | 79/125 | 0.99 (0.70, 1.39) | 0.13 |
| Pyridoxal 5’-phosphate, pmol/ml | 531/1084 | 1.10 (0.99, 1.23) | 79/125 | 0.92 (0.66, 1.28) | 0.12 |
| Homocysteine, nmol/ml | 530/1076 | 0.96 (0.85, 1.07) | 79/125 | 1.23 (0.89, 1.70) | 0.08 |
| Cysteine, nmol/ml | 530/1083 | 1.02 (0.91, 1.14) | 78/125 | 1.22 (0.86, 1.72) | 0.07 |
| Cysteinylglycine, nmol/ml | 523/1076 | 1.01 (0.90, 1.13) | 78/125 | 0.94 (0.66, 1.34) | 0.78 |
| Non-current multivitamin user at blood | Current multivitamin user at blood | ||||
| Folate, ng/mL | 343/672 | 1.08 (0.93, 1.26) | 266/533 | 1.15 (0.97, 1.36) | 0.35 |
| Vitamin B12, pg/ml | 342/672 | 1.15 (1.00, 1.33) | 266/534 | 1.29 (1.09, 1.53) | 0.17 |
| Pyridoxal 5’-phosphate, pmol/ml | 343/673 | 1.14 (0.98, 1.32) | 267/536 | 1.05 (0.90, 1.23) | 0.33 |
| Homocysteine, nmol/ml | 343/669 | 0.95 (0.83, 1.10) | 266/532 | 1.02 (0.86, 1.20) | 0.24 |
| Cysteine, nmol/ml | 342/673 | 0.90 (0.78, 1.05) | 266/535 | 1.22 (1.04, 1.44) | <0.0001 |
| Cysteinylglycine, nmol/ml | 340/670 | 0.93 (0.81, 1.07) | 261/531 | 1.09 (0.92, 1.29) | 0.009 |
*
Unconditional logistic regression with adjustments for matching factors, age at menarche, parity/age at first birth, history of breast cancer in mother or a sister, history of benign breast disease, height, body mass index at age 18, weight change since 18, and alcohol intake.