Table 3:

Prognostic value of individual features measured by the concordance index and evaluated on the independent test set. P-values are provided for the univariate analysis, for the multivariate analysis where we control for clinical and pathology variables and for multivariate analysis where we control for MR-based tumor volume.

Name of the feature	C-index (95% CI)	p-value	p-value adjusted for clinical variables	p-value adjusted for tumor volume
SER_Partial_tumor_vol_cu_mm	0.768 (0.679–0.856)	<0.0001	<0.0001	0.0016
Variance_of_RGH_values_tumor	0.304 (0.211–0.397)	0.0380	0.2471	0.0714
WashinRate_map_difference_entropy_tumor	0.325 (0.237–0.413)	0.0017	0.1479	0.0757
SER_map_Cluster_Prominence_tumor	0.303 (0.193–0.413)	0.1912	0.5704	0.2952
TumorMajorAxisLength	0.742 (0.650–0.834)	<0.0001	<0.0001	<0.0001
Mean_norm_DHOG_max_timepoint_binsize_6_with_filling_tumor	0.528 (0.449–0.607)	0.9882	0.9220	0.9853
Uptake_rate_from_char_curve_tumor	0.591 (0.483–0.699)	0.3606	0.7106	0.2998
Cluster_Shade_tumor	0.313 (0.216–0.410)	0.0003	0.0021	0.0047
PE_map_Cluster_Shade_tumor	0.366 (0.285–0.447)	0.4487	0.6798	0.5351
PE_map_Cluster_Prominence_tumor	0.307 (0.202–0.412	0.0384	0.1204	0.0695
BEDR1_tumor	0.470 (0.377–0.564)	0.6905	0.9335	0.5152
F1_T1(T11=0.02,T12=0.5)	0.488 (0.388–0.588)	0.5966	0.5001	0.6397
WashinRate_map_Correlation2_tumor	0.480 (0.385–0.575)	0.4522	0.2172	0.1202
Max_Enhancement_from_char_curve_tumor	0.583 (0.478–0.688)	0.3619	0.9434	0.3165
SER_map_Correlation2_tissue_PostCon	0.509 (0.417–0.602)	0.4454	0.3530	0.5375
BEDR2_tumor	0.473 (0.383–0.564)	0.8719	0.9582	0.7871
WashinRate_map_information_measure_correlation1_tumor	0.702 (0.601–0.803)	0.0009	0.0091	0.0015
SER_map_kurtosis_tumor	0.640 (0.521–0.760)	<0.0001	<0.0001	<0.0001
F1_T1(T11=0.05,T12=0.1)	0.527 (0.422–0.633)	0.3919	0.8115	0.3895
WashinRate_map_Autocorrelation_tissue_PostCon	0.453 (0.344–0.561)	0.5160	0.6676	0.7128