Fig. 5 |.

Nicotine reduced sensitivity to the devaluation induced passive administration of ethanol in male rats. A devaluation score of 1.0 indicates no change from baseline consumption of saccharin, any score above 1.0 indicates an increase in consumption while any score below 1.0 indicates a decrease. Nicotine administration had no effect on saccharin intake in saline-treated unconditioned controls (A). Conversely, nicotine diminished the degree of devaluation induced by increasing doses of ethanol (B). Nicotine-treated, relative to saline-treated, rats were significantly more accepting of saccharin following conditioning with 0.9, 1.8, & 2.1 g/kg ethanol, with a nonsignificant trend for increased acceptance at the 1.5 g/kg dose. In general, nicotine-treated rats were less sensitive to the devaluation induced by acute ethanol intoxication. * designates significant group difference (ps < .05).