Fig. 6 |.
Nicotine produced a significant rightward shift in the dose-response curve of ethanol-induced devaluation. Calculation of the ED50 of the curve from Fig 5B revealed that nicotine pretreatment resulted in a significant rightward shift in the dose-response curve indicating that nicotine-treated rats were less sensitive to the stimulus properties of ethanol that produce stimulus devaluation. The dose that produced a 50% decrement in saccharin intake was ~1.5 g/kg in saline-treated rats compared to ~2.0 g/kg in nicotine-treated rats. * designates significant group difference (p < .05)