Table 1.
Representative conserved orthologs with expression in fly, mouse and human adult astrocytes.
| Transcription Factors | Encoded Function(s) |
|---|---|
| Max | Myc-associated factor; cell proliferation |
| Sox5,6 | CNS development & determination of cell fate |
| Cbx1,3,5 | Histone-binding proteins |
| Jun/FosB | Major early-gene TFs |
| Crebl2 | cAMP response element (CRE)-binding protein |
| Transporters/Receptors | |
| Slc1a3 (Glast); Slc1a2 (Glt-1) | Major astrocyte glutamate transporters |
| Slc6a1 (fly Gat *) | Membrane GABA transporter |
| Gaba-a-associated | Links GABA-Areceptors to cytoskeleton |
| Gabarb1 | GABA-B receptor subunit |
| Aqp4 | Aquaporin 4 water channel |
| Npc1,2 * | Cholesterol transporters |
| ApoD | Transport of sugars and other factors |
| Egfr | Epidermal growth factor receptor |
| Ion Channels | |
| Kcnj10,16 | Potassium (K+) channels; K+ buffering |
| Grina | NMDA receptor-associated protein |
| Vdac1 | Anion channel; cell volume regulation |
| Kctd3 | Regulator of cyclic nucleotide-gated channel |
| Stim1 | Membrane Ca2+ channel; store-operated Ca2+ entry (SOCE) |
| Secreted Extracellular proteins | |
| Tgfβ2 | TGFβ receptor ligand |
| Sparcl1 | HEVIN; regulator of syaptogenesis |
| Sparc α | Antagonist of HEVIN; regulates synaptogenesis |
| Spon1 | Axon growth, guidance |
| Gliotransmission-related | |
| Snap23,25 | Regulators of neurotransmitter release |
| Synj1 | Regulates membrane phosphatidylinositol-4,5-bisphosphate |
| Syt11 | Ca2+-dependent regulation of synaptic transmission |
| Vamp2,3,4,7 | Synaptic vesicle docking and fusion |
| Stxbp1 (fly Rop *) | Regulation of neurotransmitter release |
| Vti1b | Vesicle trafficking |
| Neurotransmitter-related Enzymes | |
| Abat (fly Gabat *) | GABA transaminase |
| CSF4-U26 or Aasdh (fly Ebony *) | Aminergic neurotransmitter recycling |
| Glud1 | Glutamate/Glutamine regulation |
| Many Rab family members | GTPase; vesicle trafficking & secretion |
| Glul (fly Gs1) | Glutamine synthetase |
| GNAQ | Membrane bound GTPase linked to GPCRs |
The human gene name is shown in the first column.
*
deficits cause altered locomotor activity levels or circadian behavior in Drosophila.
α
a single Sparc gene is found in the fly genome.