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No effect of single administration of nalfurafine (10ug/kg) on anxiety-like activity in alcohol-naïve male and female mice. Anxiety-like behavior levels were measured for 5 min by elevated plus maze 30 min after nalfurafine. Data in table are presented as mean ± SEM.
| Sex | Male (n = 7–8) | Female (n = 8) | ||
|---|---|---|---|---|
| Treatment | vehicle | 10ug/kg | vehicle | 10ug/kg |
| Number of open arm entries | 11 ± 1.0 | 8.9 ± 1.2 | 10 ± 1.5 | 9.2 ± 1.1 |
| Time spent in open arms (sec) | 38 ± 4.1 | 40 ± 4.9 | 42 ± 4.5 | 39 ± 7.1 |
