Table 3.
Area under the Curve (AUC) for Pain Measures in 3 Trialsa
| Pain Scale | Average accuracy across trials | Accuracy for detecting any improvementb | Accuracy for detecting moderate improvementb | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Any improvement | Moder-ate improvement | CAMEO | SPACE | SSM | CAMEO | SPACE | SSM | |||||||
| AUC | (95% CI) | AUC | (95% CI) | AUC | (95% CI) | AUC | (95% CI) | AUC | (95% CI) | AUC | (95% CI) | |||
| PROMIS 4a | .662 | .689 | .708 | (.640−.775) | .693 | (.624−.763) | .585 | (.513−.657) | .719 | (.638−.799) | .753 | (.686−.819) | .594 | (.518−.670) |
| PROMIS 6a | .655 | .679 | .711 | (.643−.779) | .696 | (.627−.766) | .558 | (.485−.631) | .697 | (.609−.784) | .756 | (.690−.821) | .585 | (.508−.662) |
| PROMIS 8a | .647 | .677 | .704 | (.635−.773) | .677 | (.607−.748) | .560 | (.487−.633) | .697 | (.607−.786) | .749 | (.682−.817) | .586 | (.509−..663) |
| PROMIS 6b | .659 | .688 | .724 | (.657−.791) | .700 | (.630−.769) | .554 | (.480−.627) | .726 | (.641−.811) | .748 | (.680−.815) | .590 | (.513−.668) |
| PROMIS average | .656 | .683 | .712 | .692 | .564 | .710 | .752 | .589 | ||||||
| BPI Interference | .677 | .683 | .725 | (.660−.790) | .770d | (.710−.830) | .535 | (.464−.606) | .694 | (.604−.784) | .764 | (.702−.826) | .592 | (.519−.665) |
| PEG | .682 | .691 | .720 | (.654−.785) | .787d | (.728−.845) | .539 | (.467−.611) | .733 | (.647−.819) | .753 | (.691−.816) | .586 | .511−.661) |
| SF Bodily Pain | .577c | (.503−.650) | -- | -- | -- | -- | .497c | (.393−.601) | -- | -- | -- | -- | ||
| Roland-Morris | .671 | (.602−.740) | -- | -- | -- | -- | .659 | (.563−.755) | -- | -- | -- | -- | ||
a
Total N (better, same, worse) with baseline and follow-up data in CAMEO = 234 (104, 68, 62); in SPACE = 222 (134, 66, 22); and in SSM = 238 (102, 96, 40)
b
Any improvement ≥ “a little better”; moderate improvement ≥ “moderately better”; The AUC’s of the PROMIS Pain Interference short forms were mostly comparable to legacy pain measures with a few exceptions (below)
c
In CAMEO trial, the SF Bodily Pain had significantly lower accuracy in detecting any improvement and moderate improvement than the other scales (p values ranged from 0.0003 to 0.01).
d
In SPACE trial, the BPI Interference and PEG had significantly higher accuracy in detecting any improvement than the PROMIS-PI short forms.