Table 2.

Binding affinity of various sulfated NSGMs to different proteins.^a

Protein	NSGM	Binding affinity	Scaffold (N=Sulfate/Sulfonate)	Reference
Antithrombin	3 (ECS)	10.5 – 66 µM	Flavonoid monomer (N=5)	[61]
	4 ((+)-CS)	3.5 – 17.9 µM	Flavonoid monomer (N=5)	[62]
	5 ((±)-CS))	26.1 µM	Flavonoid monomer (N=5)	[62]
	6 (SQ)	17 µM	Flavonoid monomer (N=5)	[63]
	7 (SMo)	1.8 µM	Flavonoid monomer (N=5)	[63]
	9	320 µM	THIQ (N=5)	[66]
	10	1322 µM	THIQ (N=4)	[67]
	11	81 µM	THIQ (N=4)	[68]
	12	394 µM	THIQ (N=4)	[68]
	13	1 – 2.3 µM (pH=6)	Polyacrylic acid (N=0)	[157]
		34 – 180 µM (pH=7.4)
Thrombin	31	0.143 µM	Coumarin dimer (N=1)	[97]
FXIa	32 (SPGG2)	0.4 µM	Pentagalloyl pyranoside (N~10)	[98]
	33	37 µM	Quinazolinone dimer (N=2)	[101]
	34	38 µM	Quinazolinone dimer (N=2)	[101]
Plasmin	36	0.7 µM	Flavonoid dimer (N=8)	[103]
FXIIIa	37	25.3 µM	Flavonoid trimer (N=11)	[179]
CCL5	48	20 µM	Benzoic acid (N=1)	[200]

^aAll values were measured by Fluorescence Spectroscopy.