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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Acta Biomater. 2018 Dec 6;93:258–269. doi: 10.1016/j.actbio.2018.12.004

Figure 4.

Figure 4

A. Intra-cartilage equilibrium uptake of CPCs in healthy (native) and arthritic (GAG depleted) explants. Cartilage explants were trypsin treated for different durations to cause about 50% GAG depletion, representing early to mid-stage osteoarthritis (OA) and about 90% GAG depletion representing late stage OA. B. Spatial GAG distribution in cartilage slices across thickness using safranin-O staining and type II collagen staining; (i-ii) Healthy, (iii-iv) 50% and (v-vi) 90% GAG depletion. C. % CPC retained after desorption in 1x and 10x PBS over 7 days in (i-ii) 50% and (iii-iv) 90% GAG depleted cartilage explants.