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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Hepatology. 2019 Mar 10;70(2):666–681. doi: 10.1002/hep.30405

Table 1:

Predicted Activity of Transcription Factors in HNF4α-KO Mice Compared to WT Mice 2 Days Post-PH.

Day 2 Post-PH
Activated Pathways Activation z-score Inhibited Pathways Activation z-score

JUN 3.31 HNF4A −6.498
EGR1 2.814 HNF1A −4.428
RB1 2.497 Esrra −3.357
IRF3 2.42 PPARGC1A −3.228
FOXO4 2.377 NFIX −2.433
EP300 2.305 ZBTB20 −2.294
SPI1 2.248 MED1 −2.272
THRAP3 2.219 CLOCK −2.219
IRF6 2.215 NFIC −2.2
SMAD4 2.201 GATA2 −2.059
MTA1 2.194 NKX2–3 −2.04
Gm21596/Hmgb1 2.169 E2F1 −2.027
IRF7 2.163 SMAD7 −2.027
SMAD2 2.068 TAF4 −2.008
TCF3 2.022