Table 4.
Levetiracetam (n=132) |
Phenytoin (n=130) |
Both drugs (n=24) |
Total (n=286) |
|||||
---|---|---|---|---|---|---|---|---|
Events | Patients | Events | Patients | Events | Patients | Events | Patients | |
Any adverse event | 20 | 16 (12%) | 23 | 18 (14%) | 8 | 4 (17%) | 51 | 38 (13%) |
Agitation | 11 | 11 (8%) | 4 | 4 (3%) | 0 | 0 | 15 | 15 (5%) |
Hypotension | 2 | 2 (2%) | 3 | 3 (2%) | 1 | 1 (4%) | 6 | 6 (2%) |
Catheter site related | 1 | 1 (<1%) | 1 | 1 (<1%) | 3 | 2 (8%) | 5 | 4 (1%) |
Extravasation | 0 | 0 | 4 | 4 (3%) | 1 | 1 (4%) | 5 | 5 (2%) |
Tachycardia | 1 | 1 (<1%) | 3 | 3 (2%) | 1 | 1 (4%) | 5 | 5 (2%) |
Rash | 2 | 2 (2%) | 1 | 1 (<1%) | 0 | 0 | 3 | 3 (1%) |
Hypertension | 0 | 0 | 2 | 2 (2%) | 0 | 0 | 2 | 2 (<1%) |
Reaction to ceftriaxone | 0 | 0 | 0 | 0 | 1 | 1 (4%) | 1 | 1 (<1%) |
Confusion | 1 | 1 (<1%) | 0 | 0 | 0 | 0 | 1 | 1 (<1%) |
Decreased consciousness | 0 | 0 | 1 | 1 (<1%) | 0 | 0 | 1 | 1 (<1%) |
Hallucination | 1 | 1 (<1%) | 0 | 0 | 0 | 0 | 1 | 1 (<1%) |
Infusion site erythema | 0 | 0 | 1 | 1 (<1%) | 0 | 0 | 1 | 1 (<1%) |
Mechanical ventilation complication | 0 | 0 | 1 | 1 (<1%) | 0 | 0 | 1 | 1 (<1%) |
Pallor | 0 | 0 | 1 | 1 (<1%) | 0 | 0 | 1 | 1 (<1%) |
Stridor | 0 | 0 | 0 | 0 | 1 | 1 (4%) | 1 | 1 (<1%) |
Vomiting | 0 | 0 | 1 | 1 (<1%) | 0 | 0 | 1 | 1 (<1%) |
Wheezing | 1 | 1 (<1%) | 0 | 0 | 0 | 0 | 1 | 1 (<1%) |