Table 3.
In vivo bone regeneration of implants modified by PDA-assisted method.
| Materials | Surface composition | Animal model | Time | References |
|---|---|---|---|---|
| PLLA electrospun fibres | PDA coating | Mouse calvarial critical size defect | 8 weeks | [68] |
| PLGA electrospun fibres | Immobilize BFP1 onto the surface by PDA coating | Mouse calvarial critical size defect | 8 weeks | [69] |
| PLLA nanofibres | Immobilize BMP-2 onto the surface by PDA coating | Mouse calvarial critical size defect | 8 weeks | [70] |
| Ti | BMP-2–loaded PDA/HA composite coating | Bone marrow cavity of SD rats | 12 weeks | [54] |
| Ti | BMP–HA–PDA multilayer nanofilms | Medullary cavity of SD rats | 12 weeks | [73] |
| Porous Ti6Al4V scaffolds | HA/PDA coating | Rabbit femoral condylar defects | 12 weeks | [7] |
| Ti particles | Ti particle–induced calvarial osteolysis model in mice | 2 weeks | [72] |
PLLA = Poly(L-lactide); SD = Sprague-Dawley; BFP1 = bone-forming peptide 1; BMP-2 = bone morphogenic protein-2; PDA = polydopamine; PLGA = poly(lactic-co-glycolic acid).