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. 2019 Jan 7;17:103–111. doi: 10.1016/j.jot.2018.12.001

Figure 2.

Figure 2

FGFR3 deficiency results in scoliosis with decreased thoracic anteroposterior length ratio in mice. (A) Representative X-ray images of the sternum and thoracic vertebrae from WT and FGFR3-deficient mice at 2 and 8 weeks. (B) Representative 3D micro-CT images of thoracic vertebrae from WT and FGFR3-deficient mice at 8 weeks. (C) The length of thoracic vertebrae (T1–10) in FGFR3-deficient mice was increased compared with WT mice (n = 8). (D) Thoracic anteroposterior length ratio was significantly reduced in FGFR3-deficient mice (n = 8). (E) The histological section image of the affected thoracic vertebra and intervertebral disc. Red arrows point to apical vertebrae. Values are the mean ± SD. ***P < 0.001; ****P < 0.0001 compared with C3H mice. CT = computed tomography; SD = standard deviation; WT = wild-type.