Table 2.

Areas of cortical thickness significantly reduced in patients with Alzheimer’s disease compared with normal controls

Left hemisphere				Right hemisphere
Brain region	Peak vertex talairach	t	P values	Brain region	Peak vertex talairach	t	P values
	x y z				x y z
Lateral occipital cortex	−28.7 −84.1 1.6	3.109	0.003	Fusiform gyrus	28.58 −56.0 −15.0	3.345	0.001
Lingual gyrus	−24.7 −62.7 0.9	3.031	0.004	Precentral gyrus	13.4 −31.0 59.0	3.466	0.001
Superior parietal cortex	−20.5 −65.6 34.6	2.941	0.005	Entorhinal cortex	23.9 −7.1 −33.1	3.321	0.002
Precentral gyrus	−27.6 −23.2 56.4	2.85	0.006	Supramarginal gyrus	38.9 −33.9 21.9	3.013	0.004
Inferior parietal cortex	−40.2 −75.8 22.7	2.829	0.006	Pericalcarine cortex	14.3 −87.8 5.0	2.947	0.005
Isthmus cingulate cortex	−8.7 −41.8 32.0	2.721	0.009	Postcentral gyrus	14.8 −33.3 61.6	2.731	0.008
Postcentral gyrus	−41.3 −27.0 58.5	2.642	0.011	Cuneus cortex	5.3 −85.4 18.0	2.687	0.009
Cuneus cortex	−13.7 −75.7 18.2	2.632	0.011	Superior temporal gyrus	57.5 2.8 −9.4	2.675	0.010
Pericalcarine cortex	−12.7 −75.0 12.7	2.573	0.013	Inferior parietal cortex	49.8 −59.1 19.6	2.629	0.011
Insula cortex	−31.1 −25.8 10.6	2.53	0.014	Medial orbital frontal cortex	8.4 27.6 −21.9	2.561	0.013
Precuneus cortex	−12.4 −55.4 31.1	2.408	0.019	Middle temporal gyrus	56.3 −2.4 −26.0	2.579	0.013
Supramarginal gyrus	−43.4 −45.5 38.9	2.374	0.021	parahippocampal gyrus	27.6 −38.0 −11.9	2.486	0.016
Paracentral lobule	−15.6 −19.9 42.5	2.374	0.021	precuneus cortex	11.4 −56.5 18.0	2.435	0.018
Pars triangularis	−31.6 27.8 7.9	2.317	0.024	lingual gyrus	22.5 −58.4 −6.7	2.442	0.018
Posterior-cingulate cortex	−5.5 −31.6 39.7	2.314	0.024	Lateral occipital cortex	40.4 −81.0 3.3	2.439	0.018
Transverse temporal cortex	−40.0 −25.3 7.3	2.308	0.025	Caudal middle frontal gyrus	35.8 5.8 36.7	2.372	0.021
Fusiform gyrus	−37.3 −69 −16.4	2.293	0.026	Superior parietal cortex	19.5 −80.4 40.1	2.236	0.029
Rostral anterior cingulate cortex	−3.4 24.2 −2.8	2.234	0.029	Superior frontal gyrus	22.5 9.9 47.3	2.129	0.038
Caudal anterior-cingulate cortex	−4.4 20.3 19.8	2.165	0.035	Insula cortex	33.3 −21.5 11.4	2.099	0.040
Superior temporal gyrus	−51.7 −37.2 10.3	2.134	0.037	Paracentral lobule	15.5 −21.4 43.6	2.034	0.047
Superior frontal gyrus	−12.4 −8.1 45.9	2.13	0.038
Caudal middle frontal gyrus	−36.6 1.1 33.5	2.09	0.041