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. 2019 Jun 4;21(7):721–729. doi: 10.1016/j.neo.2019.04.009

Figure 2.

Figure 2

Transcriptome analysis. (A) Principal component analysis for the five DLD-1 WT biological replicates (red) and the eight DLD-1 + 13 clones (blue). (B) Correlation plots between clone 13–2 and clone 13–3 for genes (log2 ratio) on chromosome 13 (C) Correlation plots between clone 13–2 and clone 13–3 for genes (log2 ratio) on chromosome 11. (D) Chromosome-wide gene expression patterns. The ratio of significant genes on each chromosome after normalization (fold change ≥1.5, FDR ≤0.05) is shown. Each bar represents a chromosome, with chromosome 1 starting from the left. Chromosome 13 is in red and chromosome 16 is in green. (E) Genes from chromosome 11–16 were plotted according to the average log2 ratio for all clones. (F) Heat map for up-regulated (red letters) and down-regulated (blue letters) genes on chromosome 13.