Figure 1.

A. Cation-pi interactions involved in phase separation of Ddx4. B. Sliding charge analysis of Ddx4, showing charge blocks in the WT (i) but not in a charge scrambled mutant (ii). iii shows positions of phenylalanine to alanine mutants in another mutant Ddx4. C. Images showing that the above mutants reduce phase-separation propensity in cells. B and C from Nott et al. Molecular Cell (2015) 57:936–947.^{[20a, 23]}