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The Js, Qn and Kp of SCZ-NE, MCZ cream and SCZ-DMSO solution after permeating for 12 hrs
| Parameters | SCZ-DMSO solution | MCZ cream | SCZ-NEs |
|---|---|---|---|
| Qn (μg/cm2) | 57.0±15.6 | 91.4±14.5 | 171.7±20.6**,# |
| Js (μg/cm2/h) | 4.6±0.4 | 7.7±1.1 | 13.7±1.9**,# |
| Kp×10−3 (cm/h) | 0.9±0.1 | 1.5±0.2 | 2.7±0.4**,# |
Notes: Results are represented as mean±SD (n=3); #P<0.05 vs MCZ cream; **P<0.01 vs SCZ DMSO solution.
Abbreviations: Qn, cumulative penetration quality; Js, penetration rate; Kp, permeability coefficient.
