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. 2019 May 27;12:801–811. doi: 10.2147/DMSO.S206558

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© 2019 Liu et al.

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MCC950 alters the expression of key genes related to lipogenesis in the liver. (A) Hepatic lipogenesis-related genes such as SREBP-1c, FASN, and ACC1 were acutely induced by refeeding and inhibited in MCC950 treated mice. (B-D) Effects of MCC950 treatment on fatty acid β-oxidation (ACOX, CPT1α, and MCAD), transportation (CD36, and FABP1), and esterification (DGAT1) compared to that of vehicle-treated group. n=8 per group. * P˂0.05, ** P˂0.01, *** P˂0.001, and **** P˂0.0001 compared to the fasted group treated with vehicle, ^# P˂0.05 and ^#### P˂0.0001 compared to the vehicle group under the same diet treatment.