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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Glia. 2019 Mar 18;67(7):1359–1373. doi: 10.1002/glia.23611

Figure 6.

Figure 6.

C1INH ASO-treated mice have behavioral deficits without locomotor impairment. (a) Motion analysis of mice prior to on fear conditioning training (304.58±14.22 vs. 317.29±28.7, p=0.7, n=5/group). (b) Percent time immobile (post-shock) on Day 1 of fear conditioning (10.85±2.02% vs. 8.49±3.3%, p=0.55, n=5/group). (c) Decreased freezing time on Day 2 of fear conditioning in C1INH ASO-treated mice compared to control group (74.8±6.52% vs. 48.02±6.137%, T(2.942, 17), p=0.009, n=8-11/group). (d) Distance traveled over three days in an open field (2375.16±180 cm. vs. 2175.53±200 cm., p=0.7, n=3–6/group). (e) Time spent immobile is significantly greater (5.358±2.796 sec. vs. 136.7±24.88 sec., T(5.24, 8), p<0.001, n=5/group) in C1INH ASO-treated mice compared to the control group. Data are shown as mean ±SEM and were analyzed by Students t-test.