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. 2018 Mar 28;2(5):96–112. doi: 10.15698/cst2018.05.134

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Copyright: © 2018 Andriuskevicius et al.

This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.

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ssDNA generated as a result of resection or strand separation is rapidly covered by RPA (yellow spheres). Rad52 (purple spheres) binds RPA-coated ssDNA, recruits Rad51 (green spheres) and facilitates RPA-Rad51 exchange in the vicinity, thereby promoting Rad51-ssDNA filament formation. Rad55-Rad57 dimers (dark-green spheres) are also incorporated into the Rad51 nucleofilament and stabilise it by providing additional protein-protein interactions as well as antagonising Rad51 removal by Srs2 (teal ring). Only the main regulators of S. cerevisiae Rad51 are shown.