Figure 2.
Nbce1-b/c-null (KOb/c) mice exhibit reduced survival and impaired growth. (A) Mortality of 16 KOb/c mice. Eight wild-type (WT) and ten +/− littermates served as controls and survived beyond the 70 day period. (B) The weight of WT and KOb/c mice at weaning (21 days) and at 28 days. Males and females are plotted on separate axes. Mean weights±SEM at each time point are shown as filled circles and the growth trajectories of individual mice are represented as lines. Statistics are results of unpaired, one-tailed t tests between WT and KOb/c data at 21 or 28 days. (C) Representative photographs of limb bones from six WT mice and sex-matched KOb/c littermates (four male wild-type versus KOb/c pairs, two female wild-type versus KOb/c pairs, 20–43 days old). Scale bar, 5 mm. (D) The length of the six KOb/c bones normalized to their WT counterparts are shown in the graph. Statistics are results of paired, one-tailed t tests between prenormalized WT and KOb/c data for each bone type.