Table 1.
Blood analysis data
| Parameter | WT | +/− | KOb/c | Unit |
|---|---|---|---|---|
| Blood gas | ||||
| pH | 7.36±0.01 | 7.35±0.01 | 7.33±0.01 | |
| pCO2 | 36.4±2.3 | 36.5±2.2 | 44.3±2.0a | mm Hg |
| pO2 | 65.8±7.7 | 70.5±6.1 | 46.2±4.8a | mm Hg |
| HCO3− (calculated) | 20.2±1.0 | 20.1±1.0 | 23.2±0.6a | mmol/L |
| Blood chemistry | ||||
| Na+ | 143±1 | 142±1 | 142±1 | mmol/L |
| K+ | 4.85±0.27 | 4.69±0.14 | 4.54±0.22 | mmol/L |
| Ca2+ | 1.25±0.02 | 1.26±0.02 | 1.29±0.02 | mmol/L |
| Cl− | 111±1 | 111±1 | 108±1 | mmol/L |
| Blood metabolites | ||||
| Glu | 284±11 | 271±6 | 283±16 | mg/dL |
| Lac | 4.85±0.47 | 5.78±0.39 | 5.92±0.49 | mg/dL |
Blood gas, chemistry, and metabolite data from wild-type (n=11), heterozygous (n=13), and Nbce1b/c-null (n=11) littermate mice. Note that these data correspond to mixed arterial venous blood collected by cardiac puncture from anesthetized mice.
a
Significantly different from WT by ANOVA with Tukey post hoc analysis.