Table 3.

Association of change in kidney morphometry with baseline clinical measures

Change in Structural Measurement	Univariate, Pearson Correlation										Multivariate, Linear Regression Models
		Age, yr	Diabetes duration, yr	SBP, mm Hg	DBP, mm Hg	BMI, kg/m2	Hba1c, %	iGFR, ml/min	ACR, mg/g		Age, yr	Diabetes duration, yr	SBP, mm Hg	DBP, mm Hg	BMI, kg/m2	Hba1c, %	iGFR, ml/min	ACR, mg/g
ΔGBM width	r	−0.17	−0.081	0.114	0.223	0.021	0.488	0.339	0.158	β	−0.17	−0.043	0.234	0.424	0.003	−0.581	0.423	0.157
	P value	0.25	0.584	0.441	0.128	0.886	<0.001	0.018	0.282	P value	0.28	0.802	0.167	0.013	0.987	<0.001	0.022	0.345
ΔVv(Mes/glom)	r	−0.22	−0.291	0.087	0.305	0.091	0.475	0.398	0.189	β	−0.24	−0.157	0.115	0.416	0.052	0.561	0.311	0.130
	P value	0.14	0.045	0.559	0.035	0.539	<0.001	0.005	0.198	P value	0.10	0.338	0.477	0.010	0.718	<0.001	0.085	0.396
ΔSv(PGBM/glom)	r	0.14	0.126	−0.203	−0.414	−0.027	−0.446	−0.395	−0.223	β	0.18	−0.018	−0.118	−0.414	0.149	−0.485	−0.230	−0.225
	P value	0.36	0.393	0.167	0.004	0.853	0.002	0.005	0.128	P value	0.2	0.906	0.453	0.008	0.294	<0.001	0.194	0.117
ΔΜean glomerular volumea	r	−0.21	−0.157	−0.018	0.281	0.056	0.004	0.084	0.088	β	−0.27	−0.045	0.028	0.452	−0.011	0.203	−0.076	0.049
	P value	0.23	0.383	0.920	0.113	0.758	0.981	0.641	0.628	P value	0.15	0.795	0.884	0.016	0.949	0.268	0.709	0.786
ΔTotal glomerular filtration areaa	r	0.01	−0.011	−0.242	−0.164	0.057	−0.457	−0.351	−0.274	β	−0.06	−0.035	−0.189	−0.055	0.168	−0.424	−0.397	−0.209
	P value	0.94	0.954	0.175	0.363	0.751	0.008	0.046	0.123	P value	0.71	0.826	0.273	0.762	0.303	0.003	0.040	0.186
ΔMean podocyte volume	r	0.05	0.092	0.097	0.144	0.005	0.138	0.166	−0.071	β	0.006	0.078	0.098	0.197	0.067	0.063	0.233	0.119
	P value	0.74	0.534	0.512	0.328	0.975	0.350	0.259	0.633	P value	0.97	0.627	0.542	0.239	0.643	0.655	0.177	0.463
ΔVv(PC/glom)	r	0.04	0.115	−0.004	−0.127	−0.064	−0.027	−0.215	−0.023	β	0.003	0.048	−0.039	−0.051	0.044	−0.228	−0.215	−0.161
	P value	0.78	0.436	0.978	0.391	0.665	0.856	0.142	0.875	P value	0.98	0.711	0.764	0.706	0.706	0.051	0.122	0.196
ΔPodocyte number density per glomerulus	r	−0.01	−0.004	−0.072	−0.173	−0.038	−0.115	−0.237	0.039	β	0.01	−0.009	−0.091	−0.197	−0.057	−0.108	−0.295	−0.200
	P value	0.93	0.977	0.625	0.238	0.797	0.438	0.105	0.795	P value	0.93	0.953	0.572	0.228	0.687	0.434	0.082	0.228
ΔPercentage of sclerosed glomerulib	r	0.05	0.009	−0.255	−0.007	−0.291	0.177	0.043	0.125	β	−0.03	−0.120	−0.094	0.220	−0.234	0.153	0.170	0.308
	P value	0.80	0.960	0.159	0.972	0.106	0.332	0.815	0.494	P value	0.87	0.539	0.657	0.263	0.199	0.375	0.409	0.162

Missing morphometric measures because of insufficient tissue for measurement at first and/or second biopsy. Univariate models are Pearson correlations with the correlation coefficient and P value reported. Multivariate analyses are linear regression models with the β coefficient for the association of the clinical measure adjusted for age, sex, and baseline morphometry measure. Models for glomerular volume are also adjusted for glomerular volume method at baseline and the number of glomeruli assessed at first and second biopsy. Bold indicates P<0.05. SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index. n=48.

^an=33.

^bn=35.