Table 2. Analysis of Variance Comparing Regional MAO-B VT Between Patients With MDEs and Healthy Controlsa.
| Variable | MAO-B VT, Mean (SD) | Difference, % | F1,38 Score | P Value | |
|---|---|---|---|---|---|
| Patients With MDEs | Healthy Controls | ||||
| Prefrontal cortex | 34.5 (5.3) | 27.5 (4.6) | 26 | 19.6 | <.001 |
| Ventrolateral prefrontal cortex | 32.2 (7.6) | 25.6 (3.8) | 26 | 12.2 | .001 |
| Dorsolateral prefrontal cortex | 32.8 (5.5) | 28.2 (5.4) | 16 | 7.4 | .01 |
| Orbitofrontal cortex | 29.1 (4.6) | 25.7 (5.3) | 13 | 4.7 | .04 |
| Medial prefrontal cortex | 35.4 (6.2) | 32.6 (4.8) | 9 | 2.6 | .12 |
| Anterior cingulate cortex | 40.2 (6.9) | 36.3 (5.9) | 11 | 3.7 | .06 |
| Ventral striatum | 57.5 (11.5) | 53.2 (11.8) | 8 | 1.4 | .25 |
| Dorsal putamen | 47.7 (9.0) | 44.2 (7.5) | 8 | 1.8 | .19 |
| Thalamus | 54.6 (9.4) | 46.5 (7.9) | 17 | 8.8 | .005 |
| Inferior parietal cortex | 32.6 (5.5) | 28.2 (3.6) | 16 | 9.0 | .005 |
| Temporal cortex | 31.6 (4.7) | 29.3 (6.3) | 8 | 1.7 | .20 |
| Occipital cortex | 26.7 (5.5) | 24.2 (3.7) | 10 | 2.8 | .10 |
Abbreviations: MAO-B, monoamine oxidase B; MAO-B VT, MAO-B density measured by distribution volume; MDEs, major depressive episodes.
a
Analysis of variance evaluated MAO-B VT as the dependent variable and group as the predictor variable.