Table 2. Hazard Ratios for Development of Psychopathology by Infection Type in Pregnancya.
| Infection Type | Psychopathologic Condition | Adjusted Hazard Ratio (95% CI)b |
|---|---|---|
| Any maternal infection | Autism | 1.79 (1.34-2.40) |
| Depression | 1.24 (1.08-1.42) | |
| Psychosis | 1.14 (0.83-1.57) | |
| Bipolar disorderc | 0.99 (0.71-1.38) | |
| Severe maternal infection | Autism | 1.81 (1.18-2.78) |
| Depression | 1.24 (0.88-1.73) | |
| Maternal urinary tract infection | Autism | 1.89 (1.23-2.90) |
| Depression | 1.30 (1.04-1.61) |
a
All models included maternal age, maternal asthma, maternal diabetes, premature rupture of membranes, maternal tobacco status, and robust sandwich variance estimators for lack of independence among sibling births. For all models, stratification was used for 10-year epoch of birth and maternal tobacco status to avoid violating the proportional hazard assumption.
b
Bonferroni correction was used to adjust 95% CIs for 8 prespecified comparisons shown in the table.
c
Stratification was used for premature rupture of membranes and maternal age because of proportional hazards assumption violations.