Table 3.
Uni and multivariable analysis on CR status, RFS and OS in AML cohort
| Variable | Univariable | Multivariable | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CR | RFS | OS | CR | RFS | OS | ||||
| p-value | p-value | p-value | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | |
| Age group | 0.038 | 0.306 | 0.002 | 0.040 | 1.485 (1.017–2.168) | ||||
| High WBC counts | 0.880 | 0.603 | 0.929 | ||||||
| High blast percentage | 0.443 | 0.173 | 0.964 | ||||||
| Secondary AML | 0.023 | 0.243 | 0.010 | ||||||
| Cytogenetics risk groups | 0.006 | 0.001 | < 0.001 | 0.010 | 2.024 (1.188–3.449) | 0.045 | 1.400 (1.007–1.947) | < 0.001 | 2.417 (1.480–3.948) |
| High IL2RA mRNA level | 0.005 | < 0.001 | < 0.001 | 0.008 | 2.17 (1.281–5.346) | < 0.001 | 4.008 (2.437–6.592) | < 0.001 | 3.448 (1.839–6.462) |
| FLT3-ITD+ | 0.183 | 0.019 | 0.018 | ||||||
| NPM1+ | 0.963 | 0.955 | 0.507 | ||||||
| NPM1+FLT3-ITD− | 0.759 | 0.269 | 0.291 | ||||||
| c-KIT D816V+ | 0.845 | 0.022 | 0.668 | 0.015 | 3.145 (1.251–7.0901 | ||||
| CEBPADM+ | 0.998 | 0.813 | 0.061 | ||||||