Table 7.
Uni- and multivariable analyses of multiple prognostic gene expression biomarkers in cytogenetically intermediate-risk AML
| Prognostic markers | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| RFS | OS | RFS | OS | |||
| p value | p value | p value | HR (95% CI) | p value | HR (95% CI) | |
| BAALC high vs. low | 0.070 | 0.927 | ||||
| CDKN1B high vs. low | 0.229 | 0.583 | ||||
| ERG high vs. low | 0.009 | 0.001 | 0.008 | 5.541 (1.566–19.602) | ||
| MECOM/EVI1 high vs. low | 0.513 | 0.409 | ||||
| FLT3 high vs. low | 0.001 | 0.006 | 0.008 | 3.314 (1.372–8.008) | ||
| ID1 high vs. low | 0.308 | 0.216 | ||||
| IL2RA high vs. low | < 0.001 | 0.004 | < 0.001 | 8.171 (2.750–24.279) | 0.044 | 2.765 (1.028–7.437) |
| MN1 high vs. low | 0.847 | 0.211 | ||||
| WT1 high vs. low | 0.002 | 0.006 | ||||