Table 4.
Generalized Linear Model Main Effects for Pathway Fractional Anisotropy or Gray Matter Mean Diffusivity and Age Predicting Post-Traumatic Stress Cluster Scores
| Left hemisphere | Right xemisphere | |||||||
|---|---|---|---|---|---|---|---|---|
| Pathway | Region | Age | Region x Age | Region | Age | Region x Age | ||
| Factor Score | Origin | Termination | X2 (p) | X2 (p) | X2 (p) | X2 (p) | X2 (p) | X2 (p) |
| Pathway fractional anisotropy | ||||||||
| Arousal | ||||||||
| Amygdala | oPFC | 3.99 (0.046) | 5.23 (0.022) | 4.99 (0.026) | 6.43 (0.011) | |||
| rACB | 3.30 (0.069) | 6.74 (.0055) | 4.80 (0.029) | 0.48 (0.489) | 6.44 (0.011) | |||
| Hippocampus | Amygdala | 0.59 (0.467) | 6.69 (0.010) | 0.83 (0.364) | 6.45 (0.011) | |||
| oPFC | 0.95 (0.331) | 5.71 (0.017) | 0.06 (0.805) | 6.01 (0.014) | ||||
| Active avoidance | ||||||||
| Amygdala | oPFC | 0.96 (0.328) | 0.01 (0.916) | 0.64 (0.409) | 0.02 (0.886) | |||
| rACB | 0.30 (0.584) | 0.03 (0.868) | 0.47 (0.494) | 0.00 (0.965) | ||||
| Hippocampus | Amygdala | 0.01 (0.905) | 0.02 (0.896) | 4.68 (0.031) | 0.06 (0.811) | |||
| oPFC | 0.06 (0.807) | 0.01 (0.925) | 0.14 (.0704) | 0.00 (0.976) | ||||
| Emotional numbing | ||||||||
| Amygdala | oPFC | 1.19 (0.275) | 0.52 (0.473) | 0.59 (.0443) | 0.53 (0.467) | |||
| rACB | 0.38 (0.538) | 0.62 (0.432) | 2.75 (0.097) | 0.08 (0.773) | ||||
| Hippocampus | Amygdala | 0.36 (0.549) | 0.81 (0.368) | 1.10 (0.294) | 0.53 (0.465) | |||
| oPFC | 0.15 (0.704) | 0.57 (0.452) | 0.95 (0.329) | 1.11 (.0292) | ||||
| Re-experiencing | ||||||||
| Amygdala | oPFC | 1.26 (0.263) | 1.36 (0.243) | 0.83 (0.362) | 0.81 (0.368) | |||
| rACB | 0.01 (0.755) | 0.88 (0.348) | 0.64 (0.425) | 1.07 (0.301) | ||||
| Hippocampus | Amygdala | 1.25 (0.264) | 0.80 (0.372) | 0.38 (0.539) | 0.94 (0.333) | |||
| oPFC | 0.85 (0.355) | 0.98 (0.322) | 0.05 (0.826) | 0.90 (0.344) | ||||
| Gray matter mean diffusivity | ||||||||
| Arousal | ||||||||
| Amygdala | 0.08 (0.781) | 6.38 (0.012) | 0.03 (0.857) | 5.84 (0.016) | ||||
| Hippocampus | 5.11 (0.024) | 4.76 (0.029) | 4.21 (0.040) | 5.20 (0.023) | 5.20 (0.023) | 4.55 (0.033) | ||
| Active avoidance | ||||||||
| Amygdala | 0.49 (0.482) | 0.00 (0.965) | 0.28 (0.599) | 0.09 (0.759) | ||||
| Hippocampus | 0.30 (0.584) | 0.00 (0.966) | 0.18 (0.676) | 0.00 (0.994) | ||||
| Emotional numbing | ||||||||
| Amygdala | 0.07 (0.785) | 0.72 (0.396) | 0.01 (0.932) | 0.55 (0.458) | ||||
| Hippocampus | 4.27 (0.039) | 1.46 (0.227) | 1.47 (0.226) | 1.19 (0.275) | ||||
| Re-experiencing | ||||||||
| Amygdala | 0.13 (0.724) | 0.96 (0.326) | 0.61 (0.436) | 1.33 (0.249) | ||||
| Hippocampus | 0.19 (0.661) | 0.95 (0.329) | 0.08 (0.773) | 0.93 (0.335) | ||||
oPFC, orbital prefrontal cortex; rACB, rostral anterior cingulate bundle.
Scanner upgrade included as a covariate.