FIG. 3.

Breakpoint in a progressive ratio task measuring motivated operant alcohol responding 9 days post-TBI. All animals were tested for motivation to drink alcohol on a progressive ratio schedule 9 days post-TBI. Number of lever presses for an alcohol reward prior to termination of the session (breakpoint) by sham-vehicle animals (open bar), TBI-vehicle animals (black bar), and TBI-JZL184 animals (gray bar) are shown. *p < 0.05 for TBI-vehicle group compared with sham-vehicle group. #p < 0.05 for TBI-JZL184 group compared with TBI-vehicle group. Data analyzed via one-way ANOVA with Tukey's multiple comparisons test, n = 10/group. Data are expressed as mean ± SEM. ANOVA, analysis of variance; SEM, standard error of the mean; TBI, traumatic brain injury.