FIG. 3.

HU-914 is not effective in CB₂ receptor deficient mice. CB₂ receptor deficient (CB₂^-/-) mice with C57Bl/6 strain background and their wild type (WT) litter mates were treated intraperitoneally 1 h after closed-head injury with either HU-914 5 mg/kg or vehicle. HU-914 significantly improved the neurobehavioral function of WT but not of CB₂^-/- mice. Data are expressed as mean ± standard error of the mean (n = 7–17/group). *p ≤ 0.05 vs. HU-914-treated CB₂^-/- group, #p ≤ 0.05 vs. vehicle-treated WT control group.