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. 2019 Apr 24;32(4):211–220. doi: 10.1177/0891988719841728

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Expression of IL-1RI is increased; expression of MSRI is decreased on monocytes of patients with AD. PBMC of patients with AD and SC was labeled with antibodies directed against IL-1RI and MSRI. A and C, Fraction of monocytes staining positive for IL-1RI and MSRI. B and D, The mean fluorescence intensity (MFI) of the IL-1RI and the MSRI on monocytes are depicted. The ratio of IL-1RI (MFI)/MSRI (MFI) comparing the 2 populations is plotted in (E). F, The receiver operating characteristic curve (ROC) for the discrimination of patients with and without AD by the fraction of IL-1RI-positive monocytes. Trend: *P < .10; significance: *P < .05; **P < .01. AD indicates Alzheimer disease; IL-1RI, interleukin 1 receptor subtype I; MSRI, macrophage scavenger receptor I; PBMC, peripheral blood mononuclear cell; SC, symptomatic controls.