Table 1.
Patient Characteristics.a
| Symptomatic Controls (SC) | Alzheimer disease (AD) | |
|---|---|---|
| N (female) | 17 (10) | 20 (11) |
| Age | 63.6 [60.6-71.3] | 73.9 [66.3-76.1]b |
| MMSE | 29 [27-30] | 25 [23-28]c |
| Aβ 40 (ng/mL) | 15.4 [12.3-18.9] | 19.7 [16.7-23.5] |
| Aβ 42 (pg/mL) | 1262 [969-1419] | 764 [622-905] |
| Aβ ratio | 0.08 [0.08-0.10] | 0.04 [0.03-0.05] |
| t-Tau (pg/mL) | 221 [158-250] | 526 [434-596] |
| p-Tau (pg/mL) | 41.6 [29.8-56.5] | 98.6 [79.8-114.5] |
| Leukocyte counts (103/µL) | 6.4 [5.4-7.5] | 7.3 [6.0-8.4] |
| CRP (mg/L) | 2.5 [0.9-5.3] | 2.6 [0.9-5.3] |
| CD4+ (%) | 46.4 [40.9-52.0] | 44.8 [38.3-56.3] |
| CD8+ (%) | 30.8 [27.6-42.0] | 28.6 [24.8-33.9] |
| CD4/CD8 | 1.6 [1.0-1.9] | 1.6 [1.2-2.1] |
| CD14+ (%) | 21.8 [18.8- 27.4] | 25.9 [18.4-31.1] |
Abbreviations: CRP, C-reactive protein; MMSE, Mini-Mental Status Examination.
aPatient characteristics are presented as median [interquartile range]. SC include patients with depression, suspected vascular disease, or A-/T-/N- mild cognitive impairment. AD comprises patients with MCI or dementia due to Alzheimer disease. Aβ levels and tau proteins were measured in CSF, leukocyte counts, CRP, and the percentage of CD4+, CD8+, and CD14+ leukocytes were assessed in blood. Differences were calculated with the nonparametric Mann-Whitney U test. No statistical difference was calculated for the Aβ and tau levels, as they were used to define the groups.
bP < .05.
cP < .01.