Table 2.
Correlations Between the Expression of Leukocyte Receptors and Soluble IL-1 Receptor–Associated Mediators With Established AD Biomarkers, Age, and MMSE.a
| Age (SC) | Age (AD) | MMSE (AD) | Aβ 40 (AD) | Aβ 42 (AD) | Aβ Ratio (AD) | Tau (AD) | p-Tau (AD) | |
|---|---|---|---|---|---|---|---|---|
| Monocyte IL-1RI+ | 0.40 | 0.32 | −0.16 | −0.19 | −0.15 | 0.08 | 0.15 | 0.29 |
| Monocyte IL-1RI (MFI) | 0.05 | 0.34 | 0.11 | −0.19 | −0.41 | −0.05 | −0.20 | 0.03 |
| Monocyte MSRI+ | 0.04 | −0.26 | 0.34 | 0.00 | 0.20 | 0.43 | −0.11 | 0.06 |
| Monocyte MSRI (MFI) | 0.01 | −0.16 | 0.22 | −0.04 | −0.04 | 0.08 | −0.11 | −0.09 |
| Monocyte IL-RI/MSRI | 0.04 | 0.45 b | −0.10 | −0.19 | −0.26 | −0.06 | −0.01 | 0.16 |
| Lymphocyte IL-1RI+ | 0.46 | −0.11 | 0.35 | 0.33 | −0.04 | −0.55 b | −0.28 | −0.33 |
| Lymphocyte IL-1RI (MFI) | −0.37 | −0.13 | 0.34 | 0.08 | −0.24 | −0,34 | −0,44 | −0,37 |
| Lymphocyte IL-1RII+ | 0.34 | −0,19 | 0.07 | 0.22 | −0.03 | −0.15 | −0.02 | −0.33 |
| Lymphocyte IL-1RII (MFI) | 0.39 | 0.00 | 0.06 | 0.01 | −0.27 | −0.25 | −0.18 | −0.28 |
| Lymphocyte IL-1RI/IL-1RII | 0.02 | −0.15 | 0.63 c | 0.26 | 0.11 | −0.22 | −0.38 | −0.34 |
| IL-1β (plasma) | 0.14 | 0.02 | −0.01 | −0.17 | −0.31 | −0.16 | 0.06 | 0.12 |
| sIL-1RI (plasma) | −0.32 | −0.02 | 0.23 | 0.16 | 0.11 | −0.06 | −0.01 | −0.13 |
| sIL-1RII (plasma) | −0.29 | −0.26 | 0.27 | −0.06 | 0.19 | 0.23 | −0.36 | −0.39 |
| IL-1Ra (plasma) | N/A | −0.04 | 0.12 | 0.29 | 0.32 | 0.00 | −0.33 | −0.35 |
Abbreviations: AD, Alzheimer disease; IL-1RI, interleukin 1 receptor subtype I; IL-1RII indicates interleukin 1 receptor subtype II; IL-1RII, interleukin 1 receptor subtype II; MFI, mean fluorescence intensity; MMSE, Mini-Mental Status Examination; MSRI, macrophage scavenger receptor I; SC, symptomatic controls; sIL-1RI, soluble interleukin 1 receptor subtype I; sIL-1RII, soluble interleukin 1 receptor subtype II.
aCorrelations were calculated separately for patients with Alzheimer disease (AD) and symptomatic controls (SC) with the nonparametric Spearman test. For each pair of analytes, Spearman ρ is presented at the respective position in the correlation matrix. For IL-1Ra, a correlation with age could not be calculated as all values were below the lower limit of quantification and were set to 115 pg/mL as indicated. Significant correlations are written in bold letters.
bP < .05.
cP < .001.