Table 2.

Adjusted hazard ratios of all-cause mortality associated with antidepressants use during the follow-up period in all recruited patients.

Variables	28–167 cDDD				⩾168 cDDD
	HR	95% CI		p value	HR	95% CI		p value
Main modela	0.98	0.93	1.03	0.3307	0.65	0.62	0.69	<0.0001
Additional covariatesb
Main model + Severity of depression	0.97	0.92	1.02	0.2917	0.65	0.62	0.68	<0.0001
Main model + ADs use within 1 year before Index date	0.93	0.88	0.98	0.0074	0.61	0.58	0.64	<0.0001
Main model + CCI	0.97	0.92	1.02	0.2287	0.66	0.62	0.69	<0.0001
Main model + Coronary artery disease	0.97	0.92	1.02	0.2847	0.65	0.62	0.68	<0.0001
Main model + Heart failure	0.98	0.93	1.03	0.3990	0.66	0.63	0.69	<0.0001
Main model + End stage renal disease	0.98	0.93	1.03	0.3532	0.65	0.62	0.69	<0.0001
Main model + Chronic obstructive pulmonary disease	0.98	0.93	1.03	0.3320	0.66	0.63	0.69	<0.0001
Main model + Malignancy	0.97	0.92	1.02	0.2156	0.65	0.62	0.68	<0.0001
Main model + Diabetes	0.97	0.92	1.02	0.2515	0.65	0.62	0.69	<0.0001
Main model + Hypertension	0.98	0.93	1.03	0.3284	0.65	0.62	0.68	<0.0001
Main model + Donepezil	0.98	0.93	1.03	0.3856	0.66	0.63	0.69	<0.0001
Main model + Rivastigmine	0.98	0.93	1.03	0.3852	0.66	0.63	0.69	<0.0001
Main model + Galantamine	0.98	0.93	1.03	0.3499	0.65	0.62	0.69	<0.0001
Main model + Memantine	0.98	0.93	1.03	0.3467	0.66	0.63	0.69	<0.0001
Subgroup effects
Gender
Male	0.96	0.90	1.03	0.2914	0.64	0.60	0.68	<0.0001
Female	0.99	0.92	1.07	0.8169	0.67	0.62	0.72	<0.0001
Age (year)
60–80	0.99	0.92	1.06	0.7021	0.63	0.59	0.67	<0.0001
>80	0.96	0.89	1.03	0.2580	0.68	0.63	0.73	<0.0001
Severity of depression
Major depression	0.92	0.83	1.03	0.1557	0.56	0.51	0.62	<0.0001
Minor depression	0.98	0.92	1.04	0.4046	0.68	0.64	0.72	<0.0001
ADs use within 1 year before Index date
Yes	0.94	0.86	1.03	0.1835	0.60	0.55	0.66	<0.0001
No	0.92	0.86	0.98	0.0138	0.61	0.57	0.66	<0.0001

^aMain model was adjusted for gender, age, urbanization, income, and year of index date.

^bThe models were adjusted for covariates in the main model as well as each additional listed covariate.

cDDD: cumulative defined daily dosage; HR: hazard ratio; CI: confidence interval; ADs: antidepressants; CCI: Charlson comorbidity index.