Table 5.
Different antidepressant prescription and all-cause mortality analyzed by time-dependent model.
| Variables | Crude |
Adjusteda |
||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||
| SSRI | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 0.95 | 0.90 | 0.99 | 0.0289 | 0.92 | 0.88 | 0.97 | 0.0019 |
| SNRI | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 0.96 | 0.86 | 1.06 | 0.3828 | 0.93 | 0.84 | 1.04 | 0.2007 |
| NDRI | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 0.73 | 0.60 | 0.89 | 0.0016 | 0.76 | 0.63 | 0.92 | 0.0057 |
| Mirtazapine | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 1.03 | 0.92 | 1.15 | 0.6442 | 1.02 | 0.91 | 1.14 | 0.7560 |
| Tricyclic/tetracyclic ADs | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 0.81 | 0.72 | 0.92 | 0.0008 | 0.84 | 0.75 | 0.95 | 0.0064 |
| SARI | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 0.90 | 0.81 | 0.99 | 0.0319 | 0.88 | 0.80 | 0.97 | 0.0136 |
| MAOI, selective | ||||||||
| <28 cDDD | 1.00 | Reference | 1.00 | Reference | ||||
| ⩾28 cDDD | 0.69 | 0.57 | 0.84 | 0.0002 | 0.71 | 0.58 | 0.86 | 0.0007 |
a
Adjusted for all covariates including all kinds of antidepressants, gender, age, urbanization, income, and year of index date.
cDDD: cumulative defined daily dosage; SSRI: selective serotonin reuptake inhibitors; SNRI: serotonin norepinephrine reuptake inhibitor; NDRI: norepinephrine dopamine reuptake inhibitor; SARI: Serotonin antagonist and reuptake inhibitor; TCA: tricyclic antidepressant; MAOIs: monoamine oxidative inhibitor; Ads: antidepressants.