Figure 7.

Knockdown of TXNDC5 sensitizes human lung cancer cells to ER stress–induced cell death. A, knockdown of TXNDC5 (ShTX) sensitizes cells to tunicamycin-induced death. Data from six replicates are shown. B, knockdown of TXNDC5 induces a rapid response to UPR, as indicated by the accelerated splicing of XBP-1 and activation of ATF6α in the presence of tunicamycin. NS, nonspecific band. The bar graph with a dot plot indicates the quantitative results (*, p < 0.05, one-way ANOVA). Error bars, S.D.