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. 2019 Apr 18;294(22):8872–8884. doi: 10.1074/jbc.RA118.007040

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© 2019 Meng et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 7. — Loss of RIPK3 attenuates inflammation induced by dead E. coli and HMGB1. A, air-pouch lavage fluid was collected from WT and Ripk3^−/− mice following injection with live E. coli for analysis of infiltrated white blood cell (WBC) counts by microscope (left) and neutrophils (middle) and macrophages (right) by flow cytometry. B, air-pouch lavage fluid was collected from WT and Ripk3^−/− mice following injection with heat-killed E. coli for analysis of infiltrated white blood cell counts by microscope (left) and neutrophils (middle) and macrophages (right) by flow cytometry. C, WT, Trif^Lps/Lps2 mice and Il-1R^−/− mice were selected for the same experiment as B, and leukocytes (left), neutrophils (middle), and macrophages (right) numbers are shown. D, air-pouch inflammatory infiltration was induced in the absence or presence of HMGB1-neutralizing or normal control IgGs. Then air-pouch lavage fluid was collected, and leukocytes (left), neutrophils (middle), and macrophages (right) numbers are shown. Circles represent individual mice. *, p < 0.05; **, p < 0.01; ***, p < 0.001. Graphs show the mean ± S.D. from three independent experiments.